Journal for Translational Respiratory Immunology

The Journal for Translational Respiratory Immunology is a rigorous, peer-reviewed scientific journal dedicated to publishing high-impact research at the critical intersection of the respiratory system and immune defense mechanisms. Our mission is to accelerate the translation of basic scientific discoveries into actionable clinical practice, bridging the gap between laboratory research (bench) and patient care (bedside) to ultimately improve global respiratory health.

The journal provides a dynamic and comprehensive platform for researchers, clinicians, and academicians to share novel insights, experimental findings, and clinical trials. We focus on the complex biological mechanisms by which immunological and virological factors influence respiratory health and drive the pathogenesis of pulmonary diseases. The journal is committed to advancing medical science by fostering interdisciplinary collaboration among specialists in respiratory care, virology, and immunopathology.

Key Subject Areas

We welcome original research articles, comprehensive reviews, clinical trials, and case studies across the following core disciplines:

Respiratory Medicine: Research detailing the pathophysiology, diagnosis, and innovative treatments of acute and chronic airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and interstitial lung diseases.
Immunology: Investigations into the innate and adaptive immune responses within the respiratory mucosa, host-pathogen interactions, allergic responses, immunodeficiencies, and the development of targeted immunotherapeutics.
Virology: Studies focusing on the pathogenesis, epidemiology, and molecular biology of respiratory viral infections (such as Influenza, RSV, and emerging Coronaviruses), as well as vaccine efficacy and novel antiviral strategies.
Pulmonary Medicine: Clinical advancements in the management of complex pulmonary disorders, intensive care respiratory interventions, pulmonary hemodynamics, and advanced diagnostic modalities.

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Evaluating the Efficacy of Antioxidant Therapies in Mitigating Chronic Microplastic-Induced Pulmonary Inflammation

Research Paper | 2026 | Volume 1 | Issue 02 | Page 01-08 Dr Shahan Layek Independent Researcher, West Bengal, India

Predicting Intraoperative Immune Dysregulation: Machine Learning-Driven Mechanical Ventilation Profiles in Patients with Pre-existing Chronic Respiratory Disease

Original Research | 2026 | Volume 1 | Issue 1 | Page 15-19 Dr. Shahan Layek, Independent Researcher, West Bengal, India Dr. Manoj Kumar, Tutor, Department of Physiology, JHMC, WB Corresponding Author:- Dr. Manoj Kumar Tutor, Department of Physiology JHMC, WB ABSTRACT BACKGROUND: Intraoperative immune dysregulation poses a significant risk for postoperative complications in patients with pre-existing chronic respiratory disease, yet predicting these events remains clinically c

Spatial Single-Cell Profiling of the Mucosal Immune Microenvironment Across Varied Respiratory Volumes in Patients with Refractory Chronic Cough

Original Research | 2026 | Volume 1 | Issue 1 | Page 08-14 Dr. Sumit Kumar Vishwakarma, Associate Professor, Department of General Medicine, Ramkrishna Medical College, Bhopal Dr. Shahan Layek, Independent Researcher, West Bengal, India Dr. Manoj Kumar, Tutor, Department of Physiology, JHMC, WB Corresponding Author:- Dr. Manoj Kumar Tutor, Department of Physiology JHMC, WB ABSTRACT BACKGROUND: Refractory chronic cough (RCC) is characterized by persistent airway hypersensitivi

Mechanotransduction at the Alveolar-Capillary Interface: How Mechanical Strain Modulates Innate Immune Memory and Type 2 Inflammatory Cascades in Chronic Airway Diseases

Original Research | 2026 | Volume 1 | Issue 1 | Page 01-07 Dr. Manoj Kumar, Tutor, Department of Physiology, JHMC, WB Dr. Shahan Layek, Independent Researcher, West Bengal, India Corresponding Author:- Dr. Shahan Layek Independent Researcher West Bengal, India Email: layekcallmeshahan@gmail.com ABSTRACT BACKGROUND: The alveolar-capillary interface is a highly dynamic environment subjected to constant mechanical forces, including cyclic stretch and shear stress. In chronic ai

Particulate Matter (PM2.5) Exposure Accelerates Airway Remodeling via Activation of the NLRP3 Inflammasome in Moderate-to-Severe Allergic Rhinitis and Asthma

Abstract Background Fine particulate matter ($\text{PM}_{2.5}$) exposure is epidemiologically linked to the exacerbation and progression of chronic airway diseases, including allergic rhinitis and asthma (combined airway disease). However, the molecular mechanisms through which environmental particles translate into permanent structural tissue changes—a process known as airway remodeling—remain incomplete. We investigated whether $\text{PM}_{2.5}$ exposure accelerates airway

Long-Term Persistence of Dysregulated Lung-Resident Memory T Cells and Persistent Mucosal Inflammation in Post-COVID-19 Pulmonary Syndrome"

Abstract Background A significant subset of individuals recovering from acute SARS-CoV-2 infection experience Post-COVID-19 Pulmonary Syndrome (PCPS), characterized by persistent dyspnea, exercise intolerance, and chronic fibrotic or inflammatory changes on chest imaging. While systemic inflammatory markers often normalize, localized mucosal inflammation frequently endures. We investigated whether the long-term persistence and dysregulation of lung-resident memory T ($\text{T

Circulating Autoantibody Profiles as Predictive Signatures for Acute Exacerbation and Survival in Myositis-Associated Interstitial Lung Disease

Abstract Background Interstitial lung disease (ILD) is a major cause of morbidity and mortality in patients with idiopathic inflammatory myositis (IIM). The clinical course of myositis-associated ILD (myositis-ILD) is highly heterogeneous, ranging from stable, slow progression to rapidly progressive disease or devastating acute exacerbations (AE-ILD). We investigated whether specific baseline profiles of circulating myositis-specific autoantibodies (MSAs) and myositis-associa

The Interplay Between Alveolar Macrophage Polarization and Fibroblast Activation in Progressing Idiopathic Pulmonary Fibrosis (IPF)

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal lung disease characterized by aberrant tissue remodeling and alveolar destruction. While the activation of lung fibroblasts into contractile myofibroblasts is the proximate driver of extracellular matrix (ECM) deposition, the localized immune signals that sustain this fibrotic cascade remain incomplete. We investigated the specific bidirectional crosstalk between polarized alveolar ma

Quantification of Myxovirus Resistance Protein A (MxA) in Nasopharyngeal Swabs to Differentiate Viral from Bacterial Acute Respiratory Infections in Pediatric Cohorts

Abstract Background Differentiating between viral and bacterial acute respiratory infections (ARIs) in pediatric patients is a frequent diagnostic dilemma, often leading to inappropriate antibiotic prescribing. Myxovirus Resistance Protein A (MxA) is an intracellular GTPase induced specifically by type I and III interferons during active viral replication. While blood-based MxA testing is an established diagnostic method, we investigated whether quantifying MxA directly from

Immunological Correlates of Protection Induced by a Next-Generation Nasal Mucosal Vaccine Against Respiratory Syncytial Virus (RSV) in Older Adults

Abstract Background Older adults are at high risk for severe lower respiratory tract disease caused by Respiratory Syncytial Virus (RSV) due to immunosenescence. While parenterally administered prefusion F (preF) vaccines stimulate robust systemic IgG, they often fail to generate effective sterilizing immunity at the nasopharyngeal portal of entry. This study evaluated the immunological correlates of protection induced by a next-generation, nanoparticle-adjuvanted nasal mucos